Mechanisms and Applications of Citral’s Antimicrobial Properties in Food Preservation and Pharmaceuticals Formulations
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Published:2023-11-09
Issue:11
Volume:12
Page:1608
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ISSN:2079-6382
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Container-title:Antibiotics
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language:en
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Short-container-title:Antibiotics
Author:
Gutiérrez-Pacheco María Melissa1, Torres-Moreno Heriberto2ORCID, Flores-Lopez María Liliana3ORCID, Velázquez Guadarrama Norma4ORCID, Ayala-Zavala J. Fernando5ORCID, Ortega-Ramírez Luis Alberto1, López-Romero Julio César2ORCID
Affiliation:
1. Departamento de Ciencias de la Salud, Universidad Estatal de Sonora, San Luis Río Colorado 83430, Sonora, Mexico 2. Departamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, H. Caborca 83600, Sonora, Mexico 3. Centro de Investigación e Innovación Científica y Tecnológica, Universidad Autónoma de Coahuila, Saltillo 25070, Coahuila, Mexico 4. Laboratorio de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico 5. Coordinación de Tecnología de Alimentos de Origen Vegetal, Centro de Investigación en Alimentación y Desarrollo, A. C. Carretera Gustavo Astiazarán Rosas No. 46, Colonia la Victoria, Hermosillo 83304, Sonora, Mexico
Abstract
Citral is a monoterpene constituted by two isomers known as neral and geranial. It is present in different plant sources and recognized as safe (GRAS) by the Food and Drug Administration (FDA). In recent years, investigations have demonstrated that this compound exhibited several biological activities, such as antibacterial, antifungal, antibiofilm, antiparasitic, antiproliferative, anti-inflammatory, and antioxidant properties, by in vitro and in vivo assays. Additionally, when incorporated into different food matrices, citral can reduce the microbial load of pathogenic microorganisms and extend the shelf life. This compound has acceptable drug-likeness properties and does not present any violations of Lipinski’s rules, which could be used for drug development. The above shows that citral could be a compound of interest for developing food additives to extend the shelf life of animal and vegetable origin foods and develop pharmaceutical products.
Subject
Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Pharmacology, Toxicology and Pharmaceutics,Biochemistry,Microbiology
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