The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer
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Published:2023-06-30
Issue:13
Volume:24
Page:10968
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Gonzalez-Martin Roberto1, Palomar Andrea1ORCID, Quiñonero Alicia1, Pellicer Nuria1, Fernandez-Saavedra Rocio2, Conde-Vilda Estefania2, Quejido Alberto J.2, Whitehead Christine3, Scott Richard T.34, Dominguez Francisco1ORCID
Affiliation:
1. IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain 2. Unit of Mass Spectrometry and Geochemical Applications, Chemistry Division, Department of Technology, CIEMAT, 28040 Madrid, Spain 3. IVIRMA Global Research Alliance, IVI-RMA New Jersey, Basking Ridge, New Jersey, NJ 07920, USA 4. Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA 19044, USA
Abstract
Essential trace elements are required in extremely small amounts and obtained through diet. This research focuses on detecting major trace elements in different biofluids of sixty women undergoing ICSI with PGT-A and SET/FET at IVI-RMA, New Jersey, and assessing their impact on their IVF outcomes. Urine, plasma, and follicular fluid samples were collected on the vaginal oocyte retrieval day to measure the concentrations of eight essential trace elements (copper, zinc, molybdenum, lithium, selenium, manganese, chromium, and iron) using ICP-MS. After analysis, ovarian response and preimplantation outcomes had significant positive associations with both copper alone and the copper/zinc ratio in the follicular fluid and plasma, in addition to plasma manganese. Alternatively, elevated follicular fluid lithium concentrations were significantly associated with poor preimplantation outcomes while the urinary molybdenum concentration was significantly associated with a lower probability of implantation, clinical pregnancy, and live birth. Urinary lithium and chromium concentrations were significantly associated with a lower probability of achieving a live birth. Our results suggest that the essential trace elements present in follicular fluid, plasma, and urine of women are directly associated with their reproductive outcomes, with copper and manganese exerting positive effects and lithium and molybdenum exerting negative effects.
Funder
Instituto de Salud Carlos III Generalitat Valenciana
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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