The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer

Author:

Gonzalez-Martin Roberto1,Palomar Andrea1ORCID,Quiñonero Alicia1,Pellicer Nuria1,Fernandez-Saavedra Rocio2,Conde-Vilda Estefania2,Quejido Alberto J.2,Whitehead Christine3,Scott Richard T.34,Dominguez Francisco1ORCID

Affiliation:

1. IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), 46026 Valencia, Spain

2. Unit of Mass Spectrometry and Geochemical Applications, Chemistry Division, Department of Technology, CIEMAT, 28040 Madrid, Spain

3. IVIRMA Global Research Alliance, IVI-RMA New Jersey, Basking Ridge, New Jersey, NJ 07920, USA

4. Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA 19044, USA

Abstract

Essential trace elements are required in extremely small amounts and obtained through diet. This research focuses on detecting major trace elements in different biofluids of sixty women undergoing ICSI with PGT-A and SET/FET at IVI-RMA, New Jersey, and assessing their impact on their IVF outcomes. Urine, plasma, and follicular fluid samples were collected on the vaginal oocyte retrieval day to measure the concentrations of eight essential trace elements (copper, zinc, molybdenum, lithium, selenium, manganese, chromium, and iron) using ICP-MS. After analysis, ovarian response and preimplantation outcomes had significant positive associations with both copper alone and the copper/zinc ratio in the follicular fluid and plasma, in addition to plasma manganese. Alternatively, elevated follicular fluid lithium concentrations were significantly associated with poor preimplantation outcomes while the urinary molybdenum concentration was significantly associated with a lower probability of implantation, clinical pregnancy, and live birth. Urinary lithium and chromium concentrations were significantly associated with a lower probability of achieving a live birth. Our results suggest that the essential trace elements present in follicular fluid, plasma, and urine of women are directly associated with their reproductive outcomes, with copper and manganese exerting positive effects and lithium and molybdenum exerting negative effects.

Funder

Instituto de Salud Carlos III

Generalitat Valenciana

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference55 articles.

1. Female subfertility;Farquhar;Nat. Rev. Dis. Prim.,2019

2. Diagnosis and Management of Infertility: A Review;Carson;JAMA J. Am. Med. Assoc.,2021

3. Lifestyle factors and reproductive health: Taking control of your fertility;Sharma;Reprod. Biol. Endocrinol.,2013

4. Carvalho, D.C., Coelho, L.M.M., Acevedo, M.S.M.S.F., and Coelho, N.M.M. (2015). Handbook of Mineral Elements in Food, John Wiley & Sons, Ltd.

5. The essential metals for humans: A brief overview;Zoroddu;J. Inorg. Biochem.,2019

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3