Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases

Author:

Jiang Shufan12,Yang Huili1,Li Mingqing13ORCID

Affiliation:

1. Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, China

2. Shanghai Medical College, Fudan University, Shanghai 200032, China

3. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, China

Abstract

Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.

Funder

Major Research Program of the National Natural Science Foundation of China

Shanghai Natural Science Foundation

Shanghai Sailing Program

Program for Zhuoxue of Fudan University

Training Program for Famous Medical Teachers of Fudan University

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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