Affiliation:
1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
2. Shandong Saline-Alkaline Land Modern Agriculture Company, Dongying 257345, China
Abstract
Six new lipids, trichoderols B-G (1–6), along with a known one, triharzianin B (7), were isolated from the culture of Trichoderma sp. Z43 obtained from the surface of the marine brown alga Dictyopteris divaricata. Their structures and relative configurations were identified by interpretation of 1D/2D NMR and MS data. Compounds 1–7 were assayed for inhibiting the growth of three phytopathogenic fungi (Fusarium graminearum, Gaeumannomyces graminis, and Glomerella cingulata), four marine phytoplankton species (Amphidinium carterae, Heterocapsa circularisquama, Heterosigma akashiwo, and Prorocentrum donghaiense), and one marine zooplankton (Artemia salina). Compounds 1, 4, and 7 exhibited weak antifungal activities against three phytopathogenic fungi tested with MIC ≥ 64 μg/mL. All compounds displayed moderate antimicroalgal activity with IC50 ≥ 15 μg/mL and low toxicity to the brine shrimp Artemia salina.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Taishan Scholar Project Special Funding
Science & Technology Specific Projects in Agricultural High-Tech Industrial Demonstration Area of the Yellow River Delta
Subject
Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science
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