Abstract
Calmodulin (CaM) and a diversity of CaM-binding proteins (CaMBPs) are involved in the onset and progression of Alzheimer’s disease (AD). In the amyloidogenic pathway, AβPP1, BACE1 and PSEN-1 are all calcium-dependent CaMBPs as are the risk factor proteins BIN1 and TREM2. Ca2+/CaM-dependent protein kinase II (CaMKII) and calcineurin (CaN) are classic CaMBPs involved in memory and plasticity, two events impacted by AD. Coupled with these events is the production of amyloid beta monomers (Aβ) and oligomers (Aβo). The recent revelations that Aβ and Aβo each bind to both CaM and to a host of Aβ receptors that are also CaMBPs adds a new level of complexity to our understanding of the onset and progression of AD. Multiple Aβ receptors that are proven CaMBPs (e.g., NMDAR, PMCA) are involved in calcium homeostasis an early event in AD and other neurodegenerative diseases. Other CaMBPs that are Aβ receptors are AD risk factors while still others are involved in the amyloidogenic pathway. Aβ binding to receptors not only serves to control CaM’s ability to regulate critical proteins, but it is also implicated in Aβ turnover. The complexity of the Aβ/CaM/CaMBP interactions is analyzed using two events: Aβ generation and NMDAR function. The interactions between Aβ, CaM and CaMBPs reveals a new level of complexity to critical events associated with the onset and progression of AD and may help to explain the failure to develop successful therapeutic treatments for the disease.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference52 articles.
1. The amyloid hypothesis in Alzheimer disease: New insights from new therapeutics;Karen;Nature,2022
2. Kay, D.S., and Burrows, G.W. (1984). Handbook of Studies on Psychiatry and Old Age, Elsevier Science Publishers, B.V.
3. Calcium hypothesis of Alzheimer’s disease and brain aging;Khachaturian;Ann. N. Y. Acad. Sci.,1994
4. A Path toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer’s Disease;Hampel;Front. Immunol.,2020
5. Role of amyloid-β and tau proteins in Alzheimer’s disease: Confuting the amyloid cascade;Gulisano;J. Alzheimer’s Dis.,2018
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