Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway-Reference-Cited by-同舟云学术

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Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway

Published:2024-08-16 Issue: Volume: Page:
ISSN:1671-4083
Container-title:Acta Pharmacologica Sinica
language:en
Short-container-title:Acta Pharmacol Sin

Author:

Luo Zhuo-hui,Guo Jiang-shan,Pang Shuo,Dong Wei,Ma Jia-xin,Zhang Li,Qi Xiao-long,Guan Fei-fei,Gao Shan,Gao Xiang,Liu Ning,Pan Shuo,Chen Wei,Zhang Xu,Zhang Lian-feng,Yang Ya-jun

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41401-024-01362-0.pdf

Reference69 articles.

1. Cuestas Torres DM, Cardenas FP. Synaptic plasticity in Alzheimer’s disease and healthy aging. Rev Neurosci. 2020;31:245–68.

2. Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, et al. The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain. 2018;141:1917–33.

3. 2023 Alzheimer’s disease facts and figures. Alzheimers Dement. 2023;19:1598–695.

4. Loera‐Valencia R, Cedazo‐Minguez A, Kenigsberg PA, Page G, Duarte AI, Giusti P, et al. Current and emerging avenues for Alzheimer’s disease drug targets. J Intern Med. 2019;286:398–437.

5. Luo ZH, Wang YC, Pang S, Gao S, Liu N, Gao X, et al. Synthesis and bioactivity evaluation of a Novel 1,2,4-Oxadiazole derivative in vitro and in 3×Tg mice. Drug Des Dev Ther. 2022;16:3285–96.

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