The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

Author:

Chiara Veronica DellaORCID,Daxinger LuciaORCID,Staal Frank J. T.ORCID

Abstract

Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.

Publisher

MDPI AG

Subject

General Medicine

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