Author:
Xie Liping,Zeng Hedele,Sun Jianjun,Qian Wei
Abstract
Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.
Funder
National Natural Science Foundation of China
Subject
Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering
Reference170 articles.
1. Current advancement on diagnosis of ovarian cancer using biosensing of CA 125 biomarker: Analytical approaches
2. Biosensing Technologies for Medical Applications, Manufacturing, and Regenerative Medicine
3. Markets and Markets. Wearable Medical Devices Market by Device (Diagnostic (Heart, Pulse, BP, Sleep), Therapeutic (Pain, Insulin, Rehabilitation)), Application (Sport, Fitness, RPM), Type (Smartwatch, Patch), Distribution Channel (Pharmacy, Online) - Global Forecast to 2022https://www.marketsandmarkets.com/Market-Reports/wearable-medical-device-market-81753973.html?gclid=EAIaIQobChMIseq6u-345wIVQaaWCh1Iigr2EAAYASAAEgKunPD_BwE
4. Nanomaterial-based devices for point-of-care diagnostic applications
5. Microneedle, bio-microneedle and bio-inspired microneedle: A review
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