Affiliation:
1. State Key Laboratory of Targeting Oncology, National Center for International Research of Bio‐targeting Theranostics, Guangxi Key Laboratory of Bio‐targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy Guangxi Medical University Nanning Guangxi 530021 China
2. Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China
3. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health); Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325000 China
4. Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325035 China
Abstract
AbstractWound infections caused by invasive pathogens become an increasing global challenge health. Porous microneedles (MNs) present distinctive advantages for non‐invasive and in situ detection of wound infections, enabling the extraction of interstitial fluid, skin sweat, saliva and other biological samples. Consequently, porous MNs find widespread acceptance in medical detection, drug delivery, and monitoring physiological indicators. Based on these advantages, the emerging clinical applications and classifications of MNs is first introduced, covering mechanical strength, methods for antibody probe modification onto porous MNs, and signal amplification techniques for biomarkers analysis. At the same time, the specific applications of immunology and electrochemistry on porous MNs, introducing methods to enhance the detection signal of target molecules, such as rolling circle amplification, gold/silver nanoparticles, fluorescence amplification origami microneedle and so on is try to summarized. The improvement of detection sensitivity is realized by integrating various signal amplification strategies and diverse detection methods. Meanwhile, it is briefly illustrated applications in wound detections. Finally, challenges and future prospects of using porous MNs for detection in practical applications is discussed.
Funder
National Natural Science Foundation of China
University of Chinese Academy of Sciences
Basic Research Project of Wenzhou City
Scientific Research and Technology Development Program of Guangxi Zhuang Autonomous Region
Natural Science Foundation of Zhejiang Province
Subject
Industrial and Manufacturing Engineering,Mechanics of Materials,General Materials Science