Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity

Author:

Popovic MarkoORCID

Abstract

SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5 and cause a new winter wave of the COVID-19 pandemic. Omicron BA.2.75 is characterized by a greater infectivity compared to earlier Omicron variants. However, the Gibbs energy of the biosynthesis of virus particles is slightly less negative compared to those of other variants. Thus, the multiplication rate of Omicron BA.2.75 is lower than that of other SARS-CoV-2 variants. This leads to slower accumulation of newly formed virions and less damage to host cells, indicating evolution of SARS-CoV-2 toward decreasing pathogenicity.

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,Microbiology

Reference116 articles.

1. Riedel, S., Morse, S., Mietzner, T., and Miller, S. (2019). Jawetz, Melnick & Adelbergs Medical Microbiology, McGraw-Hill Education. [28th ed.].

2. Istifli, E.S., Netz, P.A., Sihoglu Tepe, A., Sarikurkcu, C., and Tepe, B. (2021). Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2). J. Biomol. Struct. Dyn., 1–12.

3. The chemical biology of coronavirus host-cell interactions;RSC Chem. Biol.,2020

4. Thermodynamic properties of human tissues;Therm. Sci.,2020

5. Standard Thermodynamic Properties, Biosynthesis Rates, and the Driving Force of Growth of Five Agricultural Plants;Front. Plant Sci.,2021

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