Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of Berberis Extract by Solid Lipid Nanoparticles for Wound Healing

Author:

Sharma Neetika1,Vasisht Karan1,Kaur Jasmine1,Sandhu Simarjot Kaur1,Dey Kaustav1,Hameed Bakr Ahmed1ORCID,Bajaj Rakesh2,Kaur Indu Pal1ORCID,Karan Maninder1

Affiliation:

1. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India

2. Nanz Med Science Pharma (P) Ltd., Paonta Sahib 173025, India

Abstract

Drug-delivery systems employing phytopharmaceuticals based on the leads in traditional knowledge offers not only an alternative but quicker and more economic strategy for drug development. Nanophytopharmaceuticals promise remarkable opportunities with the ability to overcome challenges associated with herbal medicines, such as low solubility and bioavailability, poor target specificity, and shelf life. Berberis extracts documented as Ropana (wound healer) in Sushruta Samhita are a popular traditional remedy that is amiss in the modern system of medicine as it exhibits very poor biopharmaceutical properties. Poor solubility and bioavailability necessitate the administration of high doses to achieve the desired therapeutic effects. Exploiting the diversified type of compounds with pleiotropic properties present in Berberis, the biopharmaceutical properties were engineered using an optimized freeze-dried extract and developed solid lipid nanoparticles (SLNs) as an effective drug-delivery system. An industrially viable and environment-friendly hot high-pressure homogenization technique led to a stable formulation with an average particle size of 178.4 nm, as well as a 7-fold increase in loading and a significant entrapment of 91 ± 1.25%. The pharmacodynamic studies of developed nanosystems in excision-wound models showed faster and complete healing of wounds with no scars.

Funder

University Grant Commission

Publisher

MDPI AG

Subject

Biomedical Engineering,Biomaterials

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