Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Author:

Zhang Xiaohui1,Tang Yufeng2,Lu Guangping1,Gu Junlian1

Affiliation:

1. School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan 250012, China

2. Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, China

Abstract

Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Qilu Young Scholar’s Program of Shandong University

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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