Addressing the Rising Trend in Early-Age-Onset Cancers in Canada

Author:

Wildgoose Petra1,Servidio-Italiano Filomena2,Raphael Michael J.1,Slovinec D’Angelo Monika2,Macaulay Cassandra2,Kassam Shaqil3,Nixon Nancy4,Perea José5ORCID,Hamilton Sarah6,Ramjeesingh Ravi7ORCID,Gill Sharlene6ORCID,Pollett Aaron8,Ogino Shuji9ORCID,Ugai Tomotaka10,Gupta Abha11

Affiliation:

1. Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada

2. Colorectal Cancer Resource & Action Network (CCRAN), Toronto, ON M4W 3E2, Canada

3. Southlake Stronach Regional Cancer Centre, Newmarket, ON L3Y 2P9, Canada

4. Tom Baker Cancer Centre, Calgary, AB T2N 4N2, Canada

5. Department of Medicine, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain

6. BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada

7. Nova Scotia Cancer Centre, Dalhousie University, Halifax, NS B3H 1V8, Canada

8. Division of Diagnostic Medical Genetics, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada

9. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

10. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA

11. Adolescent & Young Adult (AYA) Oncology Program, Princess Margaret Hospital, Toronto, ON M5G 2M9, Canada

Abstract

A multi-disciplinary symposium on early-age onset cancer (EAOC) was held in October 2023 to explore challenges experienced by this rapidly growing population. A major outcome of the symposium was recognition of the remarkable similarities of EAOC patients’ journeys across cancer sites. Prevention and early detection of cancer are hindered by a lack of awareness among patients and family doctors that cancer can and does occur in younger persons. Distinct characteristics of the disease—such as a later stage at diagnosis and more aggressive tumor biology—require more potent treatments, which result in profound physical and psychosocial consequences that are unique to this age group. EAOC patient empowerment emerged as another key theme of the symposium. The development of a greater number of specialized clinics was called for, and patient support groups were recognized for the vital role they play in empowering patients and their families. Leading-edge medical advancements hold tremendous hope across the spectrum of EAOC care. New technologies based on genomic profiling, immunotherapy and microbiome alteration contribute to the development of highly effective, personalized approaches to treatment. All symposium participants expressed their commitment to speak with one resounding voice to advocate for equitable access to leading care practices for EAOC patients; thus, a fourth symposium is planned for November 2024.

Funder

The U.S. National Institutes of Health

The Cancer Research UK Grand Challenge Award

The Prevent Cancer Foundation

The American Institute for Cancer Research

Publisher

MDPI AG

Reference56 articles.

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5. Canadian Cancer Statistics Advisory Committee in collaboration with the Canadian Cancer Society, Statistics Canada and the Public Health Agency of Canada (2023). Canadian Cancer Statistics 2023, Canadian Cancer Society. Available online: https://cdn.cancer.ca/-/media/files/research/cancer-statistics/2023-statistics/2023_PDF_EN.pdf.

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