Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans

Author:

Mora Ignasi1ORCID,Pérez-Santamaria Alejandra2,Tortajada-Pérez Julia34,Vázquez-Manrique Rafael P.345ORCID,Arola Lluís6ORCID,Puiggròs Francesc7

Affiliation:

1. Brudy Technology S.L., 08006 Barcelona, Spain

2. Eurecat, Centre Tecnològic de Catalunya, Nutrition and Health Unit, 43204 Reus, Spain

3. Laboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain

4. Joint Unit for Rare Diseases IIS La Fe-CIPF, 46012 Valencia, Spain

5. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28029 Madrid, Spain

6. Nutrigenomics Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, 43007 Tarragona, Spain

7. Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Tarragona, Spain

Abstract

The human lifespan has increased over the past century; however, healthspans have not kept up with this trend, especially cognitive health. Among nutrients for brain function maintenance, long-chain omega-3 polyunsaturated fatty acids (ω-3 LCPUFA): DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) must be highlighted, particularly structured forms of EPA and DHA which were developed to improve bioavailability and bioactivity in comparison with conventional ω-3 supplements. This study aims to elucidate the effect of a structured triglyceride form of DHA (DHA-TG) on the healthspan of aged C. elegans. Using a thrashing assay, the nematodes were monitored at 4, 8, and 12 days of adulthood, and DHA-TG improved its motility at every age without affecting lifespan. In addition, the treatment promoted antioxidant capacity by enhancing the activity and expression of SOD (superoxide dismutase) in the nematodes. Lastly, as the effect of DHA-TG was lost in the DAF-16 mutant strain, it might be hypothesized that the effects of DHA need DAF-16/FOXO as an intermediary. In brief, DHA-TG exerted a healthspan-promoting effect resulting in both enhanced physical fitness and increased antioxidant defense in aged C. elegans. For the first time, an improvement in locomotive function in aged wild-type nematodes is described following DHA-TG treatment.

Funder

Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) of the Catalan Government

Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation

Instituto de Salud Carlos III

Social European Funds

Publisher

MDPI AG

Subject

General Medicine

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