Detecting Square Grid Structure in an Animal Neuronal Network

Abstract

An animal neural system ranges from a cluster of a few neurons to a brain of billions. At the lower range, it is possible to test each neuron for its role across a set of environmental conditions. However, the higher range requires another approach. One method is to disentangle the organization of the neuronal network. In the case of the entorhinal cortex in a rodent, a set of neuronal cells involved in spatial location activate in a regular grid-like arrangement. Therefore, it is of interest to develop methods to find these kinds of patterns in a neural network. For this study, a square grid arrangement of neurons is quantified by network metrics and then applied for identification of square grid structure in areas of the fruit fly brain. The results show several regions with contiguous clusters of square grid arrangements in the neural network, supportive of specialization in the information processing of the system.