Abstract
Photodynamic therapy (PDT) in small animals’ oncology has been under research focus, pointing to new treatment possibilities. Moreover, several animal studies constitute experimental human disease models due to the similarity of tumor biology between animals and man. PDT uses photosensitizing compounds without toxicity per se. When subjected to a specific wavelength, the photosensitizers are activated, triggering the production of reactive oxygen species (ROS) that lead to cell death. Additionally, antiangiogenic effects and immune stimulation may also be elicited. PDT is minimally invasive, non-toxic, and does not induce carcinogenic or mutagenic side effects. Thus, it is safe for non-neoplastic tissues compared with other neoplasms treatment modalities. This review describes the applications of PDT in the cancer treatment of small animals, particularly dogs and cats, focusing on the respective photosensitizers and treatment protocols used in trials in this therapeutic modality.
Funder
Fundação para a Ciência e Tecnologia
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
Reference168 articles.
1. 2016 AAHA Oncology Guidelines for Dogs and Cats;Biller;J. Am. Anim. Hosp. Assoc.,2016
2. Villalobos, A., and Kaplan, L. (2017). Canine and Feline Geriatric Oncology, Blackwell Publishing Ltd.
3. The incidence and structure of neoplasms in animals in Dnipro city;Lieshchova;Sci. Technol. Bull. SRC Biosaf. Environ. Control AIC,2018
4. Radiation therapy planning using MRI-CT fusion in dogs and cats with brain tumors;Buchholz;Tierärztliche Prax. Ausgabe K Kleintiere/Heimtiere,2019
5. Meuten, D.J. (2016). Tumors in Domestic Animals, John Wiley & Sons. [5th ed.].
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