FKBP39 Controls the Larval Stage JH Activity and Development in Drosophila melanogaster

Author:

Wang Xinyu,Zhou Ying,Guan Jianwen,Cheng Yang,Lu Yingying,Wei YouhengORCID

Abstract

FK506-binding protein 39kD (FKBP39) localizes in the nucleus and contains multiple functional domains. Structural analysis suggests that FKBP39 might function as a transcriptional factor and control juvenile hormone (JH) activity. Here, we show that FKBP39 expresses at a high level and localizes in the nucleolus of fat body cells during the first two larval stages and early third larval stage. The fkbp39 mutant displays delayed larval-pupal transition and an increased expression of Kr-h1, the main mediator of the JH pathway, at the early third larval stage. Moreover, the fkbp39 mutant has a fertility defect that is independent of JH activity. Interestingly, the expression of rp49, the most widely used reference gene for qRT-PCR in Drosophila, significantly decreased in the fkbp39 mutant, suggesting that FKBP39 might regulate ribosome assembly. Taken together, our data demonstrate the expression pattern and physiological roles of FKBP39 in Drosophila.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Six talent peaks project in Jiangsu Province

Publisher

MDPI AG

Subject

Insect Science

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