Author:
Zhang Neng,Feng Shiqian,Tian Ye,Zhuang Ling,Cha Gan,Duan Saiya,Li Hongmei,Nong Xiangqun,Zhang Zehua,Tu Xiongbing,Wang Guangjun
Abstract
AbstractFK506 binding proteins (FKBPs) are a highly-conserved group of proteins known to bind to FK506, an immunosuppressive drug. They play different physiological roles, including transcription regulation, protein folding, signal transduction and immunosuppression. A number of FKBP genes have been identified in eukaryotes; however, very little information about these genes has been reported in Locusta migratoria. Here, we identified and characterized 10 FKBP genes from L. migratoria. Phylogenetic analysis and comparison of domain architectures indicated that the LmFKBP family can be divided into two subfamilies and five subclasses. Developmental and tissue expression pattern analysis revealed that all LmFKBPs transcripts, including LmFKBP46, LmFKBP12, LmFKBP47, LmFKBP79, LmFKBP16, LmFKBP24, LmFKBP44b, LmFKBP53, were periodically expressed during different developmental stages and mainly expressed in the fat body, hemolymph, testis, and ovary. In brief, our work depicts a outline but panoramic picture of LmFKBP family in L. migratoria, and provides a solid foundation to further investigate the molecular functions of LmFKBPs.
Funder
China Agriculture Research System of MOF and MARA
Special Investigation on National Basic Science and Technology Resources
Central Public-interest Scientific Institution Basal Research Fund
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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