Abstract
The economic activities of each city greatly shape and predict their development as well as make them more competitive both locally and globally. In the last two decades, as part of the international economic crisis, Greece has been at the center of changes that have resulted in the closure of thousands of businesses. This significantly affected Greek cities by changing their economic profile and robustness via the spatial distribution of their economic activities. Economic geography, as a sector that examines the geographical distribution of economic activities, is an important methodological base for analysing business locations and urban spatial processes. This paper aims to analyse, through a combination of economic geography theories and spatial analysis methods, the spatial patterns of economic activities and to identify urban areas that are resilient in difficult times of crisis. Thus cities that have the ability, via the proposed analysis/methodological framework, to control and evaluate their economic profile and prospects, can be transformed into smart cities by adopting ad hoc urban renaissance and resilient policies.