Role of Sirtuin 3 in Degenerative Diseases of the Central Nervous System

Author:

Zhang Haofuzi12ORCID,Dai Shuhui13,Yang Yuefan14,Wei Jialiang15,Li Xin6,Luo Peng12,Jiang Xiaofan12

Affiliation:

1. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China

2. Institute of Neurosurgery of People’s Liberation Army of China (PLA), PLA’s Key Laboratory of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China

3. National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi’an 710032, China

4. Department of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032, China

5. Department of Health Service, Fourth Military Medical University, Xi’an 710032, China

6. Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China

Abstract

An NAD+-dependent deacetylase called Sirtuin 3 (Sirt3) is involved in the metabolic processes of the mitochondria, including energy generation, the tricarboxylic acid cycle, and oxidative stress. Sirt3 activation can slow down or prevent mitochondrial dysfunction in response to neurodegenerative disorders, demonstrating a strong neuroprotective impact. The mechanism of Sirt3 in neurodegenerative illnesses has been elucidated over time; it is essential for neuron, astrocyte, and microglial function, and its primary regulatory factors include antiapoptosis, oxidative stress, and the maintenance of metabolic homeostasis. Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), may benefit from a thorough and in-depth investigation of Sirt3. In this review, we primarily cover Sirt3’s role and its regulation in the nerve cells and the connection between Sirt3 and neurodegenerative disorders.

Funder

National Natural Science Foundation of China

Youth Nova Program of Shaanxi

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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