The Effectiveness of Suffruticosol B in Treating Lung Cancer by the Laser Trapping Technique

Author:

Goangul Mulugeta S.1ORCID,Solomon Rance M.2,Devito Daniel L.2,Brown Charles A.2,Coopper James2,Erenso Daniel B.2,Gao Ying3,Pellizzaro Aline3,Revalee Jennifer M.3,Crogman Horace T.4ORCID

Affiliation:

1. Physics Department, Addis Ababa University, Addis Ababa 1000, Ethiopia

2. Departments of Physics and Astronomy, Middle Tennessee State University, Murfreesboro, TN 37132, USA

3. Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA

4. Department of Physics, California State University Dominguez Hills, Carson, CA 90747, USA

Abstract

We used laser trapping to study the effects of suffruticosol B on lung cancer cells. Physical and mechanical changes were found to be statistically significant, with a 63.97% increase over untreated cells and a 79.57% increase over untreated cells after treatment for 3 or 6 h, respectively. The treatment affected the internal structure of the cells, with changes in their elastic properties. The cellular responses showed that treatment with suffruticosol B resulted in the decreased proliferation and invasion of cancer cells. These results suggest that the treatment may be useful in preventing or treating lung cancer.

Publisher

MDPI AG

Subject

General Medicine

Reference36 articles.

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4. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Sung;CA Cancer J. Clin.,2021

5. New challenge of developing combined radio-drug therapy;Maingon;Chin. Clin. Oncol.,2014

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