Estimation of the Modified Weibull Additive Hazards Regression Model under Competing Risks

Author:

Rehman Habbiburr1ORCID,Chandra Navin2ORCID,Emura Takeshi3ORCID,Pandey Manju4

Affiliation:

1. Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA

2. Department of Statistics, Ramanujan School of Mathematical Sciences, Pondicherry University, Puducherry 605014, India

3. Biostatistics Center, Kurume University, Kurume 8300011, Japan

4. Department of Zoology and DST Centre for Mathematical Sciences, Institute of Sciences, Banaras Hindu University, Varanasi 221005, India

Abstract

The additive hazard regression model plays an important role when the excess risk is the quantity of interest compared to the relative risks, where the proportional hazard model is better. This paper discusses parametric regression analysis of survival data using the additive hazards model with competing risks in the presence of independent right censoring. In this paper, the baseline hazard function is parameterized using a modified Weibull distribution as a lifetime model. The model parameters are estimated using maximum likelihood and Bayesian estimation methods. We also derive the asymptotic confidence interval and the Bayes credible interval of the unknown parameters. The finite sample behaviour of the proposed estimators is investigated through a Monte Carlo simulation study. The proposed model is applied to liver transplant data.

Publisher

MDPI AG

Subject

Physics and Astronomy (miscellaneous),General Mathematics,Chemistry (miscellaneous),Computer Science (miscellaneous)

Reference47 articles.

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2. Cox, D.R., and Oakes, D. (1984). Analysis of Survival Data, Chapman and Hall/CRC.

3. Breslow, N.E., and Day, N.E. (1987). Statistical Methods in Cancer Research, International Agency for Research on Cancer.

4. A linear regression model for the analysis of life times;Aalen;Stat. Med.,1989

5. Semiparametric analysis of the additive risk model;Lin;Biometrika,1994

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