Affiliation:
1. Department of Oral Medicine, Institute of Dentistry, School of Medicine, Kuopio Campus, University of Eastern Finland, FI-70211 Kuopio, Finland
Abstract
The oral cavity is very diverse, wherein saliva plays an important role in maintaining oral health. The metabolism of saliva has been used to investigate oral diseases as well as general diseases, mainly to detect diagnostic biomarkers. There are many sources of salivary metabolites in the mouth. Online English language sources and the PubMed database were searched to retrieve relevant studies on oral salivary metabolites. The physiological balance of the mouth is influenced by many factors that are reflected in the salivary metabolite profile. Similarly, the dysbiosis of microbes can alter the salivary metabolite profile, which may express oral inflammation or oral diseases. This narrative review highlights the factors to be considered when examining saliva and its use as a diagnostic biofluid for different diseases. Salivary metabolites, mainly small-molecule metabolites may enter the bloodstream and cause illness elsewhere in the body. The importance of salivary metabolites produced in the oral cavity as risk factors for general diseases and their possible relationship to the body’s function are also discussed.
Funder
Finnish Dental Society, Apollonia (E.H.).
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
Reference85 articles.
1. Salivary metabolomics in the diagnosis of oral cancer and periodontal diseases;Mikkonen;J. Periodontal Res.,2016
2. Fourier Transform Infrared Spectroscopy and Photoacoustic Spectroscopy for Saliva Analysis;Mikkonen;Appl. Spectrosc.,2016
3. Hyvärinen, E., Savolainen, M., Mikkonen, J.J.W., and Kullaa, A.M. (2021). Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities. Metabolites, 11.
4. Systems Biology of Metabolism;Nielsen;Annu. Rev. Biochem.,2017
5. Developing and standardizing a protocol for quantitative proton nuclear magnetic resonance (1H NMR) spectroscopy of saliva;Gardner;J. Proteome Res.,2018
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