Thin Cationic Polymer Coatings against Foodborne Infections

Author:

Yushina Yuliya K.12ORCID,Sybachin Andrey V.3ORCID,Kuznecova Oksana A.1,Semenova Anastasia A.1ORCID,Tolordava Eteri R.12,Pigareva Vladislava A.34ORCID,Bolshakova Anastasiya V.35ORCID,Misin Vyacheslav M.6,Zezin Alexey A.37ORCID,Yaroslavov Alexander A.3,Bataeva Dagmara S.1,Kotenkova Elena A.1ORCID,Demkina Elena V.8,Reshchikov Maksim D.1

Affiliation:

1. V.M. Gorbatov Federal Research Center for Food Systems, 109316 Moscow, Russia

2. N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia

3. Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia

4. A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Science, 119334 Moscow, Russia

5. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119071 Moscow, Russia

6. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia

7. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 117393 Moscow, Russia

8. Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119991 Moscow, Russia

Abstract

Biocidal coatings are known to minimize or terminate development of bacterial and fungicidal infections. In this paper, biocidal activity of seven cationic (co)polymers with amino groups—polyethyleneimine, polyallylamine, polydiallyldimethylammonium chloride/polyhexamethylene guanidine copolymer, diallyldimethylammonium chloride/SO2 copolymer, linear and hyperbranched epichlorohydrin/dimethylamine copolymers, polydiallyldimethylammonium chloride—were tested toward Gram-positive and Gram-negative cells. The polymers showed a significant biocidal effect in both aqueous solution and after formation of polymer films on the hydrophilic glass plates. Polymer films were almost completely removed by water during 10 wash-off cycles, that finally resulted in the ultrathin monolayers with a thickness of several nanometers. A polyethyleneimine film showed the most resistance to water with a 50% loss after three wash-off cycles and 75% loss after six wash-off cycles. Binding and subsequent deactivation of pathogenic microorganisms occurs on the outer surface of cationic polymer films. It is expected that a gradual polymer wash-off will allow renewal of the outer film surface and thereby restore the biocidal properties of the polycationic coatings, including those with a nanoscale thickness.

Funder

V.M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences

Publisher

MDPI AG

Subject

Materials Chemistry,Surfaces, Coatings and Films,Surfaces and Interfaces

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