Potential Diagnostic Value of Salivary Tumor Markers in Breast, Lung and Ovarian Cancer: A Preliminary Study

Author:

Bel’skaya Lyudmila V.12ORCID,Sarf Elena A.1,Loginova Alexandra I.34,Vyushkov Dmitry M.34,Choi En Djun5

Affiliation:

1. Biochemistry Research Laboratory, Omsk State Pedagogical University, 14, Tukhachevsky Str., 644099 Omsk, Russia

2. Department of Biochemistry, Omsk State Medical University, 12, Lenina Str., 644099 Omsk, Russia

3. Clinical Oncology Dispensary, 9/1, Zavertyayeva Str., 644013 Omsk, Russia

4. Department of Oncology, Omsk State Medical University, 12, Lenina Str., 644099 Omsk, Russia

5. Clinic Lekar, 14/4, Presnensky Val Str., 107031 Moscow, Russia

Abstract

The aim of the study was to determine the content of tumor markers for breast, lung and ovarian cancer in saliva, as well as for benign diseases of the corresponding organs and in the control group, and to evaluate their diagnostic significance. Strictly before the start of treatment, saliva samples were obtained and the concentrations of tumor markers (AFP, NSE, HE4, CA15-3, CA72-4, CA125 and CEA) were determined using an enzyme immunoassay (ELISA). CA125 and HE4 were simultaneously determined to be in the blood serum of patients with ovarian cancer. The concentrations of salivary CEA, NSE, CA15-3, CA72-4 and CA125 of the control group were significantly lower than in oncological diseases; however, these tumor markers also increased in saliva with benign diseases. The content of tumor markers depends on the stage of cancer, and the presence of lymph node metastasis; however, the identified patterns are statistically unreliable. The determination of HE4 and AFP in saliva was not informative. In general, the area of potential use of tumor markers in saliva is extremely narrow. Thus, CEA may be diagnostic for breast and lung cancer, but not for ovarian cancer. CA72-4 is most informative for ovarian mucinous carcinoma. None of the markers showed significant differences between malignant and non-malignant pathologies.

Publisher

MDPI AG

Subject

Microbiology (medical),Molecular Biology,General Medicine,Microbiology

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