Saliva – a new opportunity for fluid biopsy-Reference-Cited by-同舟云学术

Saliva – a new opportunity for fluid biopsy

Published:2022-10-27 Issue:1 Volume:61 Page:4-32
ISSN:1434-6621
Container-title:Clinical Chemistry and Laboratory Medicine (CCLM)
language:en
Short-container-title:

Author:

Huang Zhijie¹^ORCID,Yang Xiaoxia²,Huang Yisheng¹,Tang Zhengming¹,Chen Yuanxin¹,Liu Hongyu¹,Huang Mingshu¹,Qing Ling¹,Li Li¹,Wang Qin¹,Jie Zhuye³⁴⁵,Jin Xin³⁶,Jia Bo¹

Affiliation:

1. Department of Oral Surgery, Stomatological Hospital , Southern Medical University , Guangzhou , P.R. China

2. Department of Endodontics, Stomatological Hospital , Southern Medical University , Guangzhou , P.R. China

3. BGI Genomics, BGI-Shenzhen , Shenzhen , P.R. China

4. Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen , Shenzhen , P.R. China

5. Laboratory of Genomics and Molecular Biomedicine, Department of Biology , University of Copenhagen , Copenhagen , Denmark

6. School of Medicine , South China University of Technology , Guangzhou , P.R. China

Abstract

Abstract Saliva is a complex biological fluid with a variety of biomolecules, such as DNA, RNA, proteins, metabolites and microbiota, which can be used for the screening and diagnosis of many diseases. In addition, saliva has the characteristics of simple collection, non-invasive and convenient storage, which gives it the potential to replace blood as a new main body of fluid biopsy, and it is an excellent biological diagnostic fluid. This review integrates recent studies and summarizes the research contents of salivaomics and the research progress of saliva in early diagnosis of oral and systemic diseases. This review aims to explore the value and prospect of saliva diagnosis in clinical application.

Funder

Natural Science Foundation of Guangdong Province

Research and Cultivation Project of Stomatological Hospital, Southern Medical University

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Link

https://www.degruyter.com/document/doi/10.1515/cclm-2022-0793/pdf

Reference263 articles.

1. Vaidyanathan, R, Soon, RH, Zhang, P, Jiang, K, Lim, CT. Cancer diagnosis: from tumor to liquid biopsy and beyond. Lab Chip 2018;19:11–34. https://doi.org/10.1039/c8lc00684a.

2. Ye, Q, Ling, S, Zheng, S, Xu, X. Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA. Mol Cancer 2019;18:114. https://doi.org/10.1186/s12943-019-1043-x.

3. Remon, J, Majem, M. EGFR mutation heterogeneity and mixed response to EGFR tyrosine kinase inhibitors of non small cell lung cancer: a clue to overcoming resistance. Transl Lung Cancer Res 2013;2:445–8.

4. Allott, EH, Geradts, J, Sun, X, Cohen, SM, Zirpoli, GR, Khoury, T, et al.. Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification. Breast Cancer Res 2016;18:68. https://doi.org/10.1186/s13058-016-0725-1.

5. Poulet, G, Massias, J, Taly, V. Liquid biopsy: general concepts. Acta Cytol 2019;63:449–55. https://doi.org/10.1159/000499337.

Cited by 27 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Response to the letter to the editor;Oral Diseases;2024-06-24

2. Comparative salivary proteomics analysis of children with and without early childhood caries using the DIA approach: A pilot study;PROTEOMICS – Clinical Applications;2024-05-20

3. Salivary Tryptophan as a Metabolic Marker of HER2-Negative Molecular Subtypes of Breast Cancer;Metabolites;2024-04-25

4. The emerging role of liquid biopsy in oral squamous cell carcinoma detection: advantages and challenges;Expert Review of Molecular Diagnostics;2024-04-02

5. Salivary extracellular vesicles isolation methods impact the robustness of downstream biomarkers detection;2024-01-23