Synthesis, Structure and Antimicrobial Activity of New Co(II) Complex with bis-Morpholino/Benzoimidazole-s-Triazine Ligand
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Published:2023-06-29
Issue:7
Volume:11
Page:278
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ISSN:2304-6740
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Container-title:Inorganics
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language:en
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Short-container-title:Inorganics
Author:
Soliman Saied M.1, Fathalla Eman M.1, Sharaf Mona M.2, El-Faham Ayman1, Barakat Assem3ORCID, Haukka Matti4ORCID, Slawin Alexandra M. Z.5ORCID, Woollins John Derek56ORCID, Abu-Youssef Morsy A. M.1
Affiliation:
1. Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt 2. Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, Alexandria P.O. Box 21933, Egypt 3. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 4. Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014 Jyväskylä, Finland 5. School of Chemistry, University of St Andrews, St Andrews KY16 9ST, UK 6. Department of Chemistry, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates
Abstract
A new Co(II) perchlorate complex of the bis-morpholino/benzoimidazole-s-triazine ligand, 4,4′-(6-(1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine (BMBIT), was synthesized and characterized. The structure of the new Co(II) complex was approved to be [Co(BMBIT)2(H2O)4](ClO4)2*H2O using single-crystal X-ray diffraction. The Co(II) complex was found crystallized in the monoclinic crystal system and P21/c space group. The unit cell parameters are a = 22.21971(11) Å, b = 8.86743(4) Å, c = 24.38673(12) Å and β = 113.4401(6)°. This heteroleptic complex has distorted octahedral coordination geometry with two monodenatate BMBIT ligand units via the benzoimidazole N-atom and four water molecules as monodentate ligands. The hydration water and perchlorate ions participated significantly in the supramolecular structure of the [Co(BMBIT)2(H2O)4](ClO4)2*H2O complex. Analysis of dnorm map and a fingerprint plot indicated the importance of O···H, N···H, C···H, C···O, C···N and H···H contacts. Their percentages are 27.5, 7.9, 14.0, 0.9, 2.8 and 43.5%, respectively. The sensitivity of some harmful microbes towards the studied compounds was investigated. The Co(II) complex has good antifungal activity compared to the free BMBIT which has no antifungal activity. The Co(II) complex has good activity against B. subtilis, S. aureus, P. vulgaris and E. coli while the free BMBIT ligand has limited activity only towards B. subtilis and P. vulgaris. Hence, the [Co(BMBIT)2(H2O)4](ClO4)2*H2O complex has broad spectrum antimicrobial action compared to the free BMBIT ligand.
Funder
Researchers Supporting Project
Subject
Inorganic Chemistry
Reference46 articles.
1. Sun, H., Chen, S., Zhong, A., Sun, R., Jin, J., Yang, J., Liu, D., Niu, J., and Lu, S. (2023). Tuning Photophysical Properties via Positional Isomerization of the Pyridine Ring in Donor–Acceptor-Structured Aggregation-Induced Emission Luminogens Based on Phenylmethylene Pyridineacetonitrile Derivatives. Molecules, 28. 2. Ye, D., Liu, L., Peng, Q., Qiu, J., Gong, H., Zhong, A., and Liu, S. (2023). Effect of Controlling Thiophene Rings on D-A Polymer Photocatalysts Accessed via Direct Arylation for Hydrogen Production. Molecules, 28. 3. On the origin and nature of internal methyl rotation barriers: An information-theoretic approach study;Wang;Theor. Chem. Acc.,2022 4. Zhang, W., Ye, G., Liao, D., Chen, X., Lu, C., Ejhieh, A.N., Khan, M.S., Liu, J., Pan, Y., and Dai, Z. (2022). Recent Advances of Silver-Based Coordination Polymers on Antibacterial Applications. Molecules, 27. 5. Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs;Chen;Dalton Trans.,2023
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