The Application of Ethnomedicine in Modulating Megakaryocyte Differentiation and Platelet Counts

Author:

Yang Fei12,Lai Jia12,Deng Junzhu3,Du Jun2,Du Xi2,Zhang Xiaoqin2,Wang Yiwei2,Huang Qianqian1,Xu Qian2,Yang Gang2,Zhang Yanjun2,Zhou Xilan2,Zhang Xiao2,Yuan Yuan2,Zhang Chunxiang4,Wu Jianming245ORCID

Affiliation:

1. School of Pharmacy, Southwest Medical University, Luzhou 646000, China

2. School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, China

3. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

4. Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China

5. Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Southwest Medical University, Luzhou 646000, China

Abstract

Megakaryocytes (MKs), a kind of functional hematopoietic stem cell, form platelets to maintain platelet balance through cell differentiation and maturation. In recent years, the incidence of blood diseases such as thrombocytopenia has increased, but these diseases cannot be fundamentally solved. The platelets produced by MKs can treat thrombocytopenia-associated diseases in the body, and myeloid differentiation induced by MKs has the potential to improve myelosuppression and erythroleukemia. Currently, ethnomedicine is extensively used in the clinical treatment of blood diseases, and the recent literature has reported that many phytomedicines can improve the disease status through MK differentiation. This paper reviewed the effects of botanical drugs on megakaryocytic differentiation covering the period 1994–2022, and information was obtained from PubMed, Web of Science and Google Scholar. In conclusions, we summarized the role and molecular mechanism of many typical botanical drugs in promoting megakaryocyte differentiation in vivo, providing evidence as much as possible for botanical drugs treating thrombocytopenia and other related diseases in the future.

Funder

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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