First Characterization of Novel Silicon Carbide Detectors with Ultra-High Dose Rate Electron Beams for FLASH Radiotherapy

Author:

Romano Francesco12,Milluzzo Giuliana1,Di Martino Fabio34,D’Oca Maria Cristina15ORCID,Felici Giuseppe6ORCID,Galante Federica6,Gasparini Alessia78ORCID,Mariani Giulia6,Marrale Maurizio15ORCID,Medina Elisabetta910ORCID,Pacitti Matteo6,Sangregorio Enrico1112ORCID,Vanreusel Verdi813,Verellen Dirk78,Vignati Anna910,Camarda Massimo1415

Affiliation:

1. Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Catania, 95123 Catania, Italy

2. Particle Therapy Research Center (PARTREC), Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Zernikelaan 25, 9747 AA Groningen, The Netherlands

3. Centro Pisano Ricerca e Implementazione Clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, 56126 Pisa, Italy

4. UO Fisica Sanitaria, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy

5. Dipartimento di Fisica e Chimica “Emilio Segrè”, Università di Palermo, 90128 Palermo, Italy

6. SIT-Sordina, 36100 Vicenza, Italy

7. Iridium Network, Radiotherapy, 2610 Wilrijk, Belgium

8. Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Wilrijk, Belgium

9. Dipartimento di Fisica, Università degli Studi di Torino, 10125 Torino, Italy

10. INFN Sezione di Torino, 10124 Torino, Italy

11. Dipartimento di Fisica e Astronomia, Università degli Studi di Catania, 95124 Catania, Italy

12. CNR—Istituto per la Microelettronica e Microsistemi, 95121 Catania, Italy

13. SCK CEN Research in Dosimetric Applications, 2400 Mol, Belgium

14. STLab srl, Via Anapo 53, 95126 Catania, Italy

15. SenSiC, DeliveryLab, 5232 Villigen, Switzerland

Abstract

Ultra-high dose rate (UHDR) beams for FLASH radiotherapy present significant dosimetric challenges. Although novel approaches for decreasing or correcting ion recombination in ionization chambers are being proposed, applicability of ionimetric dosimetry to UHDR beams is still under investigation. Solid-state sensors have been recently investigated as a valuable alternative for real-time measurements, especially for relative dosimetry and beam monitoring. Among them, Silicon Carbide (SiC) represents a very promising candidate, compromising between the maturity of Silicon and the robustness of diamond. Its features allow for large area sensors and high electric fields, required to avoid ion recombination in UHDR beams. In this study, we present simulations and experimental measurements with the low energy UHDR electron beams accelerated with the ElectronFLASH machine developed by the SIT Sordina company (IT). The response of a newly developed 1 × 1 cm2 SiC sensor in charge as a function of the dose-per-pulse and its radiation hardness up to a total delivered dose of 90 kGy, was investigated during a dedicated experimental campaign, which is, to our knowledge, the first characterization ever done of SiC with UHDR-pulsed beams accelerated by a dedicated ElectronFLASH LINAC. Results are encouraging and show a linear response of the SiC detector up to 2 Gy/pulse and a variation in the charge per pulse measured for a cumulative delivered dose of 90 kGy, within ±0.75%.

Funder

INFN CSN5

Missione 4 Istruzione e Ricerca-Componente 2-Investimento 1.5 (“PNRR”), NGEU

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

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