Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice-Reference-Cited by-同舟云学术

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Published:2014-07-16 Issue:245 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Favaudon Vincent¹²,Caplier Laura³,Monceau Virginie⁴⁵,Pouzoulet Frédéric¹²,Sayarath Mano¹²,Fouillade Charles¹²,Poupon Marie-France¹²,Brito Isabel⁶⁷,Hupé Philippe⁶⁷⁸⁹,Bourhis Jean⁴⁵¹⁰,Hall Janet¹²,Fontaine Jean-Jacques³,Vozenin Marie-Catherine⁴⁵¹⁰¹¹

Affiliation:

1. Institut Curie, Centre de Recherche, 91405 Orsay, France.

2. INSERM U612, 91405 Orsay, France.

3. Pathology Laboratory, Ecole Nationale Vétérinaire d’Alfort, Université Paris-Est, 94704 Maisons Alfort, France.

4. Université Paris-XI, 91405 Orsay, France.

5. INSERM U1030, Institut Gustave-Roussy, 94805 Villejuif, France.

6. Institut Curie, Centre de Recherche, 75248 Paris 05, France.

7. INSERM U900, 75248 Paris 05, France.

8. Mines ParisTech, 77305 Fontainebleau, France.

9. CNRS, UMR144, 75248 Paris 05, France.

10. Radio-Oncologie/Radiothérapie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.

11. INSERM U967, Commissariat à l’Énergie Atomique (CEA), Division des Sciences du Vivant (DSV), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), 92265 Fontenay aux Roses, France.

Abstract

Pulsed, ultrahigh dose-rate irradiation is safer than standard radiotherapy for the treatment of lung cancer and selectively spares normal tissue.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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