Author:
Fu Siqi,Du Canwei,Zhang Qijian,Liu Jiayu,Zhang Xushuang,Deng Meichun
Abstract
Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a novel wound-healing promoting peptide, PM-7, was identified from the skin secretions of Polypedates megacephalus, which has an amino acid sequence of FLNWRRILFLKVVR and shares no structural similarity with any peptides described before. It displays the activity of promoting wound healing in mice. Moreover, PM-7 exhibits the function of enhancing proliferation and migration in HUVEC and HSF cells by affecting the MAPK signaling pathway. Considering its favorable traits as a novel peptide that significantly promotes wound healing, PM-7 can be a potential candidate in the development of novel wound-repairing drugs.
Funder
Natural Science Foundation of Hunan Province
National Natural Science Foundation of China
Innovation and entrepreneurship education reform research project of Central South University
Postgraduate education and teaching reform project of Central South University
Biochemistry Maker Space of Central South University
Subject
Health, Toxicology and Mutagenesis,Toxicology
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