Author:
Razali Masfueh,Ngeow Wei Cheong,Omar Ros Anita,Chai Wen Lin
Abstract
Titanium is widely used as an implanted material in various clinical applications, especially in orthopedics and dental implantology. Following manufacturing and storage, titanium dental implants have the ability to undergo aging, which renders a reduction in osteoblast cellular activity during the healing process, so advancement of a surface treatment to recreate bioactive implant surfaces are required. Ultra-violet (UV) surface treatment has been introduced as a potential solution to reverse the aging process via removal of hydrocarbon contamination on the surface. This narrative review aimed to discuss the current understanding of the mechanism of titanium aging and provide insights into the mechanism that improves the biocompatibility of titanium implants following UV treatment. Additionally, the findings from preclinical and clinical studies is integratively presented. A reference search was performed through the PubMed, Embase, and Scopus databases based on the keywords titanium degradation, titanium aging, photofunctionalization, and UV treatment. Emerging data demonstrated the positive effect of UV light on osteoblast cells with enhanced alkaline phosphatase activity in vitro and increased bone-implant contact in animal studies. Despite limited human studies, the data reported here appear to support the benefit of UV light photofunctionalization on titanium surfaces as an alternative to reverse the titanium aging process. The direction of future research should focus on prospective randomized blinded clinical trials.
Funder
Ministry of Higher Education, Malaysia
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
Reference105 articles.
1. Biological aging of implant surface and their restoration with ultraviolet treatment: A novel understanding of osseointegration;Att;Int. J. Oral Maxillofac. Implants,2012
2. The Biological Aging of Titanium Implants
3. Intra-Osseous Anchorage of Dental Prostheses:I. Experimental Studies
4. Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes;Ogawa;Int. J. Oral Maxillofac. Implants,2003
5. A histomorphometric evaluation of bone-to-implant Eontact on machine-prepared roughened titanium and dental implants. A pilot study in the dog.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献