Prostate Cancer Radiogenomics—From Imaging to Molecular Characterization

Author:

Ferro MatteoORCID,de Cobelli Ottavio,Vartolomei Mihai Dorin,Lucarelli GiuseppeORCID,Crocetto FeliceORCID,Barone BiagioORCID,Sciarra Alessandro,Del Giudice FrancescoORCID,Muto Matteo,Maggi MartinaORCID,Carrieri Giuseppe,Busetto Gian MariaORCID,Falagario Ugo,Terracciano DanielaORCID,Cormio Luigi,Musi Gennaro,Tataru Octavian SabinORCID

Abstract

Radiomics and genomics represent two of the most promising fields of cancer research, designed to improve the risk stratification and disease management of patients with prostate cancer (PCa). Radiomics involves a conversion of imaging derivate quantitative features using manual or automated algorithms, enhancing existing data through mathematical analysis. This could increase the clinical value in PCa management. To extract features from imaging methods such as magnetic resonance imaging (MRI), the empiric nature of the analysis using machine learning and artificial intelligence could help make the best clinical decisions. Genomics information can be explained or decoded by radiomics. The development of methodologies can create more-efficient predictive models and can better characterize the molecular features of PCa. Additionally, the identification of new imaging biomarkers can overcome the known heterogeneity of PCa, by non-invasive radiological assessment of the whole specific organ. In the future, the validation of recent findings, in large, randomized cohorts of PCa patients, can establish the role of radiogenomics. Briefly, we aimed to review the current literature of highly quantitative and qualitative results from well-designed studies for the diagnoses, treatment, and follow-up of prostate cancer, based on radiomics, genomics and radiogenomics research.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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