Association of Serum Antioxidant Minerals and Type 2 Diabetes Mellitus in Chinese Urban Residents

Author:

He Jingjing,Chen Fangyan,Wan Sitong,Luo YongtingORCID,Luo JunjieORCID,He Shuli,Zhou DaizhanORCID,An PengORCID,Zeng Ping

Abstract

Antioxidant minerals including zinc, copper and selenium play critical roles in the maintenance of the redox balance in the body. However, their influences on type 2 diabetes mellitus (T2DM) are still inconclusive in Chinese populations. To elucidate the relationship between antioxidant minerals and T2DM, serum zinc, copper and selenium concentrations were measured in 1443 Chinese urban residents using a 1:2 matched case-control study. Conditional logistic regression models (CLR) were used to obtain the odds ratios (ORs) and 95% confidence intervals (CIs), and restricted cubic splines (RCS) were used to examine their dose–response associations. Serum zinc (OR = 0.52 [0.35, 0.77]) and copper concentrations (OR = 0.25 [0.17, 0.37]) were negatively associated with T2DM in a fully adjusted model. An L-shaped zinc-T2DM association (Poverall association = 0.003, and Pnonlinearity = 0.005) and a negative linear copper-T2DM association (Poverall association < 0.0001, and Pnonlinearity = 0.395) were observed. No association was found between serum selenium and T2DM in fully adjusted CLR or RCS models. In addition, joint associations with T2DM were identified between serum zinc and copper and between serum selenium and copper. In conclusion, our study emphasizes the importance of an adequate intake of antioxidant minerals for T2DM prevention in the Chinese population.

Funder

National Nutrition Science Research Grant

National Natural Science Foundation of China

Chinese Universities Scientific Fund

Beijing Municipal Natural Science Foundation

Publisher

MDPI AG

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology

Reference47 articles.

1. Epidemiology of Type 2 Diabetes—Global Burden of Disease and Forecasted Trends;Khan;J. Epidemiol. Glob. Health,2019

2. Type 2 Diabetes in Adolescents and Young Adults;Lascar;Lancet Diabetes Endocrinol.,2018

3. Interpreting Global Trends in Type 2 Diabetes Complications and Mortality;Ali;Diabetologia,2022

4. Current Lifestyle Factors That Increase Risk of T2DM in China;Zhang;Eur. J. Clin. Nutr.,2017

5. GBD 2017 Diet Collaborators (2019). Health Effects of Dietary Risks in 195 Countries, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017. Lancet, 393, 1958–1972.

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