Oxidative Stress and Antioxidants in Chronic Rhinosinusitis with Nasal Polyps

Author:

Tai JunhuORCID,Shin Jae-Min,Park Jaehyung,Han MunsooORCID,Kim Tae Hoon

Abstract

Oxidative stress results from an imbalance between the production of reactive oxygen species and the body’s antioxidant defense system. It plays an important role in the regulation of the immune response and can be a pathogenic factor in various diseases. Chronic rhinosinusitis (CRS) is a complex and heterogeneous disease with various phenotypes and endotypes. Recently, an increasing number of studies have proposed that oxidative stress (caused by both environmental and intrinsic stimuli) plays an important role in the pathogenesis and persistence of CRS. This has attracted the attention of several researchers. The relationship between the presence of reactive oxygen species composed of free radicals and nasal polyp pathology is a key topic receiving attention. This article reviews the role of oxidative stress in respiratory diseases, particularly CRS, and introduces potential therapeutic antioxidants that may offer targeted treatment for CRS.

Funder

Basic Science Research Program of the National Research Foundation

Ministry of Science and Technology

Ministry of Science, ICT, and Future Planning of Korea

Institute for Information and Communications Technology Planning and Evaluation

ICT Creative Consilience program

Korea Health Technology R&D Project

Korea Health Industry Development Institute

Ministry of Health and Welfare

Korea University

Korea University Medical Center and Anam Hospital in Seoul

Publisher

MDPI AG

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology

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