Abstract
Oxidative stress results from an imbalance between the production of reactive oxygen species and the body’s antioxidant defense system. It plays an important role in the regulation of the immune response and can be a pathogenic factor in various diseases. Chronic rhinosinusitis (CRS) is a complex and heterogeneous disease with various phenotypes and endotypes. Recently, an increasing number of studies have proposed that oxidative stress (caused by both environmental and intrinsic stimuli) plays an important role in the pathogenesis and persistence of CRS. This has attracted the attention of several researchers. The relationship between the presence of reactive oxygen species composed of free radicals and nasal polyp pathology is a key topic receiving attention. This article reviews the role of oxidative stress in respiratory diseases, particularly CRS, and introduces potential therapeutic antioxidants that may offer targeted treatment for CRS.
Funder
Basic Science Research Program of the National Research Foundation
Ministry of Science and Technology
Ministry of Science, ICT, and Future Planning of Korea
Institute for Information and Communications Technology Planning and Evaluation
ICT Creative Consilience program
Korea Health Technology R&D Project
Korea Health Industry Development Institute
Ministry of Health and Welfare
Korea University
Korea University Medical Center and Anam Hospital in Seoul
Subject
Cell Biology,Clinical Biochemistry,Molecular Biology,Biochemistry,Physiology
Cited by
6 articles.
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