Levels of nasal nitric oxide and nitric oxide synthase expression in chronic rhinosinusitis with nasal polyposis

Author:

Wu Vincent1ORCID,Cusimano Michael2,Marsden Philip3,Lee John M.1ORCID

Affiliation:

1. Division of Rhinology Department of Otolaryngology – Head and Neck Surgery St. Michael's Hospital, Unity Health Toronto University of Toronto Toronto Canada

2. Division of Neurosurgery Department of Surgery St. Michael's Hospital, Unity Health Toronto University of Toronto Toronto Canada

3. Keenan Research Centre, St. Michael's Hospital University of Toronto Toronto Canada

Abstract

Key points CRSwNP patients had decreased nNO and increased SNOT‐22, endoscopy, and CT scores. CRSwNP patients exhibited decreased nNO despite elevated iNOS and eNOS mRNA expression. The mechanism behind lowered nNO in CRSwNP may not be related to NOS expression.

Publisher

Wiley

Subject

Otorhinolaryngology,Immunology and Allergy

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