Baculovirus Display of Peptides and Proteins for Medical Applications

Author:

Rodríguez-Hernández Aaron Pavel1,Martínez-Flores Daniel1ORCID,Cruz-Reséndiz Adolfo2,Padilla-Flores Teresa1,González-Flores Rodrigo1ORCID,Estrada Kenia1ORCID,Sampieri Alicia1,Camacho-Zarco Aldo Román3,Vaca Luis1ORCID

Affiliation:

1. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico

2. Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico

3. European Molecular Biology Laboratory, Grenoble Outstation, EMBL Grenoble, CEDEX 9, 38042 Grenoble, France

Abstract

Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.

Funder

Dirección General de Asuntos del Personal Académico

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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