Commercial Vaccines Do Not Confer Protection against Two Genogroups of Piscirickettsia salmonis, LF-89 and EM-90, in Atlantic Salmon

Author:

Figueroa Carolina,Torrealba DéboraORCID,Morales-Lange ByronORCID,Mercado Luis,Dixon BrianORCID,Conejeros Pablo,Silva Gabriela,Soto Carlos,Gallardo José A.ORCID

Abstract

In Atlantic salmon, vaccines have failed to control and prevent Piscirickettsiosis, for reasons that remain elusive. In this study, we report the efficacy of two commercial vaccines developed with the Piscirickettsia salmonis isolates AL100005 and AL 20542 against another two genogroups which are considered highly and ubiquitously prevalent in Chile: LF-89 and EM-90. Two cohabitation trials were performed to mimic field conditions and vaccine performance: (1) post-smolt fish were challenged with a single infection of LF-89, (2) adults were coinfected with EM-90, and a low level coinfection of sea lice. In the first trial, the vaccine delayed smolt mortalities by two days; however, unvaccinated and vaccinated fish did not show significant differences in survival (unvaccinated: 60.3%, vaccinated: 56.7%; p = 0.28). In the second trial, mortality started three days later for vaccinated fish than unvaccinated fish. However, unvaccinated and vaccinated fish did not show significant differences in survival (unvaccinated: 64.6%, vaccinated: 60.2%, p = 0.58). Thus, we found no evidence that the evaluated vaccines confer effective protection against the genogroups LF-89 and EM-90 of P. salmonis with estimated relative survival proportions (RPSs) of −9% and −12%, respectively. More studies are necessary to evaluate whether pathogen heterogeneity is a key determinant of the lack of vaccine efficacy against P. salmonis.

Publisher

MDPI AG

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology

Reference36 articles.

1. Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective

2. Piscirickettsiosis and Piscirickettsia salmonis in fish: a review

3. Informe Sanitario Salmonicultura en Centros Marinos 2019,2020

4. Rickettsial septicemia in farmed Atlantic and chinook salmon in British Columbia: Clinical presentation and experimental transmission;Brocklebank;Can. Vet. J.,1993

5. Rickettsia-like organism in farmed salmon;Grant;Vet. Rec.,1996

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