Exosomes in the Diagnosis of Neuropsychiatric Diseases: A Review-Reference-Cited by-同舟云学术

Exosomes in the Diagnosis of Neuropsychiatric Diseases: A Review

Published:2024-05-28 Issue:6 Volume:13 Page:387
ISSN:2079-7737
Container-title:Biology
language:en
Short-container-title:Biology

Author:

Wu Song¹²³,Shang Xinmiao¹²³,Guo Meng¹²³,Su Lei⁴^ORCID,Wang Jun¹²³

Affiliation:

1. Autism & Depression Diagnosis and Intervention Institute, Hubei University of Technology, Wuhan 430068, China

2. National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan 430068, China

3. Cooperative Innovation Center of Industrial Fermentation, Ministry of Education & Hubei Province, Hubei University of Technology, Wuhan 430068, China

4. Shenzhen Key Laboratory of Nano-Biosensing Technology, Marshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China

Abstract

Exosomes are 30–150 nm small extracellular vesicles (sEVs) which are highly stable and encapsulated by a phospholipid bilayer. Exosomes contain proteins, lipids, RNAs (mRNAs, microRNAs/miRNAs, long non-coding RNAs/lncRNAs), and DNA of their parent cell. In pathological conditions, the composition of exosomes is altered, making exosomes a potential source of biomarkers for disease diagnosis. Exosomes can cross the blood–brain barrier (BBB), which is an advantage for using exosomes in the diagnosis of central nervous system (CNS) diseases. Neuropsychiatric diseases belong to the CNS diseases, and many potential diagnostic markers have been identified for neuropsychiatric diseases. Here, we review the potential diagnostic markers of exosomes in neuropsychiatric diseases and discuss the potential application of exosomal biomarkers in the early and accurate diagnosis of these diseases. Additionally, we outline the limitations and future directions of exosomes in the diagnosis of neuropsychiatric diseases.

Funder

Ministry of Science and Technology of the People’s Republic of China

National Natural Science Foundation of China International Collaborative

Hubei Provincial Department of Education

Department of Science and Technology of Hubei Province

Publisher

MDPI AG

Link

https://www.mdpi.com/2079-7737/13/6/387/pdf

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