Developing Botanical Formulations for Sustainable Cosmetics

Author:

Lima Lonetá Lauro1ORCID,Bispo-dos-Santos Karina2,Trevisan Ingrid Mayara Cavalcante3,Rapôso Catarina3,Velho Paulo Eduardo Neves Ferreira4,Bagatin Ediléia5ORCID,Rezende Rodrigo Alvarenga16,da Silva Jorge Vicente Lopes1ORCID,Ricci Leonardi Gislaine23ORCID

Affiliation:

1. 3D Technologies Research Group (NT3D), Renato Archer Information Technology Center-CTI, Campinas 13069901, Brazil

2. Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas 13083970, Brazil

3. Faculty of Pharmaceutical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas 13083871, Brazil

4. Department of Medicine, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas 13083970, Brazil

5. Department of Dermatology, Federal University of São Paulo-UNIFESP, São Paulo 04039001, Brazil

6. Postgraduate Program in Biotechnology, University of Araraquara (UNIARA), Araraquara 14801340, Brazil

Abstract

Interest in clean beauty is rising due to minimalism in the formulation of cosmetics, rational use of water, and fewer chemical additives like preservatives, colorants, surfactants, and artificial fragrances. Green ingredients lead to the development of sustainable formulations with advanced performance and are less aggressive to human health and the environment. Currently, the electrospinning technique is used as a simple one-step manufacturing process to produce nanostructured cosmetics under mild temperature conditions. This study focuses on the utilization of rice bran oil (RBO) in the creation of sustainable nanostructured cosmetics for potential cosmetic and well-being applications. Four sustainable formulations were developed to optimize the creation of nanostructured cosmetics using ethyl cellulose and rice bran oil (RBO). Ethanol absolute and polyvinyl pyrrolidone have been chosen to compose the sustainable formulation due to their biocompatibility and biodegradability. We studied four different RBO concentrations regarding morphology, encapsulation efficiency, biodegradability, and cytotoxicity. Nanostructured cosmetics present biomimetic surfaces, high RBO encapsulation ability, low mass loss at simulated physiologic conditions, and non-cytotoxicity. Therefore, the minimalist sustainable formulation does not contain any toxic solvents and incompatible harmful excipients, was nanostructured using a mild manufacturing process, and obtained high RBO entrapment.

Funder

CAPES

Publisher

MDPI AG

Subject

Dermatology,Pharmaceutical Science,Aging,Chemical Engineering (miscellaneous),Surgery

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