From Waste to Health: Olive Mill Wastewater for Cardiovascular Disease Prevention

Author:

Mattioli Laura Beatrice1,Corazza Ivan2ORCID,Budriesi Roberta1ORCID,Hrelia Silvana3ORCID,Malaguti Marco3ORCID,Caliceti Cristiana4ORCID,Amoroso Rosa5ORCID,Maccallini Cristina5ORCID,Crupi Pasquale6ORCID,Clodoveo Maria Lisa7ORCID,Muraglia Marilena8ORCID,Carocci Alessia8ORCID,Tardugno Roberta8ORCID,Barbarossa Alexia8,Corbo Filomena8ORCID

Affiliation:

1. Food Chemistry and Nutraceutical Lab, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy

2. Department of Medical and Surgical Science (DIMEC), Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy

3. Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d’Augusto 237, 47921 Rimini, Italy

4. Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy

5. Department of Pharmacy, University ‘G. d’Annunzio’ of Chieti-Pescara, 66100 Chieti, Italy

6. Department of Agricultural, Food and Forestry Sciences, University of Palermo, V. Le Delle Scienze 13, 90128 Palermo, Italy

7. Interdisciplinary Department of Medicine, School of Medicine, University of Bari ‘Aldo Moro, 70124 Bari, Italy

8. Department of Pharmacy—Drug Science, University of Bari ‘Aldo Moro’, 70125 Bari, Italy

Abstract

Waste from the agri-food chain represents a valuable reservoir of organic compounds with health-promoting properties. Momast Plus 30 Bio (MP30B) is a derivative obtained from olive-oil wastewater. Its enrichment in hydroxytyrosol (HT) via a patented technique has paved the way for its potential application as a dietary supplement in preventing cardiovascular diseases. MP30B demonstrates no significant alteration in cardiac and vascular parameters in “ex vivo” studies. However, it exhibits a strong ability to remove reactive oxygen species and exerts anti-inflammatory effects, notably reducing the concentration of iNOS and mitigating heart infections in “in vitro” experiments. Furthermore, MP30B slightly decreases the stiffness of the “ex vivo” thoracic aorta, potentially resulting in lowered arterial pressure and enhanced energy transfer to a normal ventricle. Based on these findings, we posit MP30B as a promising extract for cardiovascular disease prevention, and its specific antibacterial properties suggest its utility in preventing cardiac infections.

Funder

MUR-PRIN-2022

University of Bologna

Publisher

MDPI AG

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