C-Reactive Protein as a Marker of Inflammation in Children and Adolescents with Metabolic Syndrome: A Systematic Review and Meta-Analysis
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Published:2023-11-02
Issue:11
Volume:11
Page:2961
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ISSN:2227-9059
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Container-title:Biomedicines
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language:en
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Short-container-title:Biomedicines
Author:
Podeanu Mihaela-Andreea1, Turcu-Stiolica Adina2ORCID, Subțirelu Mihaela Simona2ORCID, Stepan Mioara Desdemona3ORCID, Ionele Claudiu-Marinel4ORCID, Gheonea Dan-Ionuț4, Vintilescu Bianca Ștefănița3ORCID, Sandu Raluca Elena5ORCID
Affiliation:
1. Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 2. Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 3. Department of Infant Care, Pediatrics and Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 4. Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 5. Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Abstract
Metabolic syndrome (MetS) in the pediatric population has been reported in many studies to be associated with an inflammatory response. However, to our knowledge, there is no definitive conclusion in the form of a meta-analysis. The issue we aimed to address is whether C-reactive protein (CRP) is a trustworthy marker in detecting inflammation in children and adolescents with MetS. We systematically searched PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, the ISI Web of Science, and SCOPUS until 31 June 2023 for studies involving children and adolescents with MetS where hsCRP or CRP were measured. After the screening process, we identified 24 full-text articles that compared 930 patients with MetS with either healthy (n = 3782) or obese (n = 1658) controls. The risk of bias in the included studies was assessed using the Begg’s rank correlation test and Egger’s regression test. Statistical analysis was carried out based on pooled mean differences (MDs) and an associated 95% CI. Data analysis showed that MetS is associated with higher levels of CRP than those in healthy controls (MD = 1.28, 95% CI: (0.49–2.08), p = 0.002) in obese patients (MD = 0.88, 95% CI: (0.38–1.39), p = 0.0006). However, conventional methods of CRP analysis were found to be more accurate in differentiating between children and adolescents with obesity and those with MetS, compared with hsCRP (MD = 0.60, 95% CI: (−0.08–1.28), p = 0.08). No risk of bias was assessed. In conclusion, CRP is a reliable inflammatory marker for differentiating pediatric patients with MetS from healthy ones. On the other hand, it did not prove to be very accurate in distinguishing between patients who had MetS and those who were obese. There should be more research performed in this field.
Funder
University of Medicine and Pharmacy of Craiova, Romania
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference77 articles.
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