Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Author:

Solano-Pérez Esther12,Coso Carlota12,Castillo-García María134,Romero-Peralta Sofía134,Lopez-Monzoni Sonia1,Laviña Eduardo1,Cano-Pumarega Irene25ORCID,Sánchez-de-la-Torre Manuel267,García-Río Francisco28910ORCID,Mediano Olga123ORCID

Affiliation:

1. Sleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain

3. Medicine Department, Universidad de Alcalá, 28805 Madrid, Spain

4. Sleep Research Institute, 28036 Madrid, Spain

5. Sleep Unit, Pneumology Department, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain

6. Group of Precision Medicine in Chronic Diseases, University Hospital Arnau de Vilanova and Santa María, 25198 Lleida, Spain

7. Department of Nursing and Physiotherapy, Faculty of Nursing and Physiotherapy, Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, 25002 Lleida, Spain

8. Respiratory Diseases Group, Respiratory Service, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, Spain

9. Pneumology Department, Hospital Universitario La Paz, IdiPAZ, 28046 Madrid, Spain

10. Faculty of Medicine, Universidad Autónoma de Madrid, 28049 Madrid, Spain

Abstract

Obstructive sleep apnea (OSA) in children is a prevalent, but still, today, underdiagnosed illness, which consists of repetitive episodes of upper airway obstruction during sleep with important repercussions for sleep quality. OSA has relevant consequences in the pediatric population, mainly in the metabolic, cardiovascular (CV), and neurological spheres. However, contrary to adults, advances in diagnostic and therapeutic management have been scarce in the last few years despite the increasing scientific evidence of the deleterious consequences of pediatric OSA. The problem of underdiagnosis and the lack of response to treatment in some groups make an update to the management of OSA in children necessary. Probably, the heterogeneity of OSA is not well represented by the classical clinical presentation and severity parameters (apnea/hypopnea index (AHI)), and new strategies are required. A specific and consensus definition should be established. Additionally, the role of simplified methods in the diagnosis algorithm should be considered. Finally, the search for new biomarkers for risk stratification is needed in this population. In conclusion, new paradigms based on personalized medicine should be implemented in this population.

Funder

ISCIII

Spanish Respiratory Society

Menarini Laboratories

Publisher

MDPI AG

Subject

General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)

Reference90 articles.

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