Abstract
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference32 articles.
1. Peripheral Arterial Disease
2. The “DEBELLUM”—Lower limb multilevel treatment with drug eluting balloon—Randomized trial: 1-year results;Fanelli;J. Cardiovasc. Surg.,2014
3. Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents
4. Inhibition of Restenosis in Femoropopliteal Arteries
5. Role of nitinol stent fractures in the development of in-stent restenosis in the superficial femoral artery;Babaev;Vasc. Dis. Manag.,2016
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献