(E)-1-(5-Methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one Oxime-Reference-Cited by-同舟云学术

(E)-1-(5-Methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one Oxime

Published:2023-02-21 Issue:1 Volume:2023 Page:M1593
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Abdel-Wahab Bakr F.¹,Farahat Abdelbasset A.²³,Kariuki Benson M.⁴^ORCID,El-Hiti Gamal A.⁵^ORCID

Affiliation:

1. Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt

2. Master of Pharmaceutical Sciences Program, California Northstate University, Elk Grove, CA 95757, USA

3. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

4. School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK

5. Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia

Abstract

The reaction of 1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (1) with excess hydroxylamine hydrochloride (2 mole equivalents) in dry ethanol afforded (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one oxime (2) in 86% yield. The structure of the new heterocycle 2 was confirmed using nuclear magnetic resonance spectroscopy, single crystal X-ray and elemental analysis.

Funder

King Saud University

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2023/1/M1593/pdf

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