2-((4-Amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one
Author:
Abdel-Wahab Bakr F.1, Mabied Ahmed F.2ORCID, Fettinger James C.3, Farahat Abdelbasset A.45
Affiliation:
1. Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt 2. X-ray Crystallography Lab., Solid State Physics Department, Physics Research Institute, National Research Centre, Dokki, Giza 12622, Egypt 3. Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616, USA 4. Master of Pharmaceutical Sciences Program, California Northstate University, Elk Grove, CA 95757, USA 5. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Abstract
The reaction of 2-bromo-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (1) with 4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazole-3-thiol (2) in absolute ethanol in the presence of triethyl amine as catalyst gave 2-((4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (3) in 73% yield. The structure of the title heterocycle (3) was confirmed by X-ray single crystal diffraction and spectral analyses (NMR and IR).
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
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