Affiliation:
1. IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy
2. Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy
Abstract
Cardiovascular disease, the leading cause of death worldwide, has been characterized at the molecular level by alterations in gene expression that contribute to the etiology of the disease. Such alterations have been shown to play a critical role in the development of atherosclerosis, cardiac remodeling, and age-related heart failure. Although much is now known about the cellular and molecular mechanisms in this context, the role of epigenetics in the onset of cardiovascular disease remains unclear. Epigenetics, a complex network of mechanisms that regulate gene expression independently of changes to the DNA sequence, has been highly implicated in the loss of homeostasis and the aberrant activation of a myriad of cellular pathways. More specifically, non-coding RNAs have been gaining much attention as epigenetic regulators of various pathologies. In this review, we will provide an overview of the ncRNAs involved in cell-to-cell communication in cardiovascular disease, namely atherosclerosis, cardiac remodeling, and cardiac ageing, and the potential use of epigenetic drugs as novel therapeutic targets.
Funder
European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference102 articles.
1. Epidemiology of cardiovascular disease in Europe;Townsend;Nat. Rev. Cardiol.,2022
2. Prevalence, incidence and survival of heart failure: A systematic review;Johnson;Heart,2022
3. Overview of microRNA biogenesis, mechanisms of actions, and circulation;Hayder;Front. Endocrinol.,2018
4. Long noncoding RNA: A new player of heart failure?;Papait;J. Cardiovasc. Transl. Res.,2013
5. Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy;Chatterjee;Circulation,2016
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