Abstract
In the present study, we analyzed the combination of non-toxic concentrations per se, of Cd and a pesticide the imidacloprid (IMI) (10 and 50 μM for Cd and 195 μM for IMI), to highlight early developmental toxicity and possible damage to retinal cells. Co-exposure to Cd and IMI showed a toxic effect in zebrafish larval development, with lowered degrees of survival and hatching, and in some cases the induction of structural alterations and edema. In addition, co-exposure to 50 and 195 μM, respectively, for Cd and IMI, also showed increased apoptosis in eye cells, accompanied by up regulation of genes associated with antioxidant markers (cat, sod1, nrf2 and ho-1). Thus, the present study aims to highlight how the presence of multiple contaminants, even at low concentrations, can be a risk factor in a model of zebrafish (Danio rerio). The presence of other contaminants, such as IMI, can cause an enhancement of the toxic action of Cd on morphological changes in the early life stage of zebrafish, but more importantly disrupt the normal development of the retina, eventually triggering apoptosis.
Subject
General Veterinary,Animal Science and Zoology
Reference66 articles.
1. Van Dijk, T.C., Van Staalduinen, M.A., and Van der Sluijs, J.P. (2013). Macro-invertebrate decline in surface water polluted with imidacloprid. PLoS ONE, 8.
2. Systemic insecticides (neonicotinoids and fipronil): Trends, uses, mode of action and metabolites;Belzunces;Environ. Sci. Pollut. Res.,2015
3. Environmental fate and exposure; neonicotinoids and fipronil;Bonmatin;Environ. Sci. Pollut. Res.,2015
4. How a complete pesticide screening changes the assessment of surface water quality;Moschet;Environ. Sci. Technol.,2014
5. Cumulative ecological impacts of two successive annual treatments of imidacloprid and fipronil on aquatic communities of paddy mesocosms;Hayasaka;Ecotoxicol. Environ. Saf.,2012
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献