Abstract
The measurement of biological tissues’ dielectric properties plays a crucial role in determining the state of health, and recent studies have reported microwave biosensing to be an innovative method with great potential in this field. Research has been conducted from the tissue level to the cellular level but, to date, cellular adhesion has never been considered. In addition, conventional systems for diagnosing tumor aggressiveness, such as a biopsy, are rather expensive and invasive. Here, we propose a novel microwave approach for biosensing adherent cancer cells with different malignancy degrees. A circular patch resonator was designed adjusting its structure to a standard Petri dish and a network analyzer was employed. Then, the resonator was realized and used to test two groups of different cancer cell lines, based on various tumor types and aggressiveness: low- and high-aggressive osteosarcoma cell lines (SaOS-2 and 143B, respectively), and low- and high-aggressive breast cancer cell lines (MCF-7 and MDA-MB-231, respectively). The experimental results showed that the sensitivity of the sensor was high, in particular when measuring the resonant frequency. Finally, the sensor showed a good ability to distinguish low-metastatic and high-metastatic cells, paving the way to the development of more complex measurement systems for noninvasive tissue diagnosis.
Funder
Sapienza University of Rome
Subject
Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry
Reference57 articles.
1. Dielectric Properties Measurement and PH Analysis for Drinking Water;Hoon,2021
2. A Comparative Evaluation of Patch Resonators Layouts for Moisture Measurement in Historic Masonry Units;D’Alvia;Proceedings of the 2019 IMEKO TC4 International Conference on Metrology for Archaeology and Cultural Heritage,2019
3. Permittivity-Based Water Content Calibration Measurement in Wood-Based Cultural Heritage: A Preliminary Study
4. Broadband Dielectric Properties of Ex Vivo Bovine Liver Tissue Characterized at Ablative Temperatures
5. Measurement and applications of dielectric properties of agricultural products
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