Antifungal Activity of Angelica gigas with Enhanced Water Solubility of Decursin and Decursinol Angelate by Hot-Melt Extrusion Technology against Candida albicans

Abstract

Hot-melt extrusion (HME) has been an alternative technique to improve the solubility and bioavailability of active molecules with low water solubility. In this study, HME-Angelica gigas Nakai (AGN) was prepared to increase the aqueous solubility of decursin (D) and decursinol angelate (DA), the active ingredients of AGN. Compared with unprocessed AGN, HME-AGN showed enhanced water solubility of D and DA. The HME-AGN exhibited improved antioxidant activity by the DPPH radical scavenging method. The antifungal activity was confirmed against Candida albicans (C. albicans). There was a decrease in CFU in the plate treated with the HME-AGN extract compared with the plate treated with the AGN extract, and F2 showed the highest antifungal activity.